http://support.skype.com/index.php?_a=knowledgebase&_j=questiondetails&_i=68Can I use Skype with Windows 98 or Windows ME?
Because it hasn't been fully tested, we have not yet certified Skype for use with these operating systems. Skype may work with Windows 98 (Win98)or ME but we cannot yet guarantee compatibility. Some WinME/9x video (and possibly others) drivers tend to use 100% of processor for their needs for relatively long periods of time. This can cause the audio quality to degrade significantly. In addition, WinME/9x does not offer full unicode support, which means that some things may not display properly. Skype does not work on WinNT at the moment. We may support these platforms in the future and will make any future announcements on our website.
Sådan som jeg læser svaret så står der måske, den install der ligger på nettet til w2k skulle kunne køre, men der er ingen garenti for et ordentligt resultat.